Since the 1930s, therapeutics have tended to be produced in tablet or capsule form as first target formulation.  Although this formulation works well for many products – and is acceptable for many patients – studies suggest that around 37% of patients struggle to swallow tablets/capsules.  For many patients with neurological conditions, the mechanics of swallowing can be impaired; for patients with psychiatric conditions part of the condition may involve poor insight about, or hostility to medication.   Patients undergoing surgery or associated treatment to their throat area can suffer from subsequent swallowing difficulties as well.  Percentages of patients struggling with these secondary swallowing difficulties can reach as high as 90% in subsets of patients with the primary neurological condition.